Available for Android and iOS devices. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. The mention of any product, service, or therapy is not an endorsement by NCCIH. Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. People sometimes eat the stem and leaves of milk thistle in salads. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. Bethesda, MD 20894, Web Policies People with diabetes often have high cholesterol. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Medicinal use of this product has not been approved by the FDA. Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. In a mini Review on the Chemistry and Neuroprotective Effects of Silymarin, published in 2017, researchers went so far as to say that silymarin promotes the inhibition of the inflammatory response generated during neurodegeneration.. Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles. One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. Click here for an email preview. Effects of Silybum marianum (L.) Gaertn. Accessed Oct. 30, 2020. Summary In animals, milk thistle has been shown to stimulate bone mineralization. This publication is not copyrighted and is in the public domain. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Hepatology. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. These include: Summary Milk thistle is generally considered safe. information is beneficial, we may combine your email and website usage information with 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. However, there is a lack of . Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. 1. https://iocdf.org/about-ocd/ocd-treatment/meds/, International OCD Foundation, Medications for OCD, By By Michael Jenike, MD, Retrieved May 5, 2019, 2. https://theoakstreatment.com/blog/ocd-facts-and-statistics/, The Oaks Treatment, OCD Facts and Statistics, Published June 18, 2018, Retrieved May 5, 2019, 3. https://www.psycom.net/ocd-medication-guide/, Psycom.net, OCD Medication Guide, By Kathleen Smith, PhD, Last Updated September 21, 2018, 4. https://www.ncbi.nlm.nih.gov/pubmed/20564545, Phtotherapy Research, Milk thistle in liver diseases: past, present, future, Published October 24, 2010, Retrieved May 5, 2019, 5. https://www.drugs.com/npp/milk-thistle.html, Drugs.com, Milk Thistle, Last updated on Mar 1, 2019, Retrieved May 5, 2019, 6. https://www.verywellhealth.com/the-benefits-of-milk-thistle-88325, VeryWellHealth.com, The Benefits of Milk Thistle, By Kathee Wong, Updated March 08, 2019, Retrieved May 5, 2019, 7. https://linkinghub.elsevier.com/retrieve/pii/S0944711315000227, Phytomedicine, Effects of Silybum marianum (L.) Gaertn. Digestion and Depression . Int J Mol Sci. By using our site, you acknowledge that you have read and understand our. Call our friendly customer service team at 1-800-569-4994 Weekdays 9am-12:30pm and 1:30pm-5pm EST, Get health news, exclusive offers, and more. Milk thistle. However, this is the only clinical study available. Silymarin as supportive treatment in liver diseases: a narrative review. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. However, few of these claims are supported by solid evidence. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. It is primarily considered a cleansing agent and used to block or flush toxins from the body. You may opt-out of email communications at any time by clicking on Multiple Myeloma vs. Leukemia: What Are the Differences? other information we have about you. https://www.wolterskluwercdi.com/facts-comparisons-online/. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Milk thistle is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita phalloides (death cap) mushroom poisoning, jaundice, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Get the facts on milk thistle for the liver. One important detoxifying ingredient is milk thistle. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Healthline Media does not provide medical advice, diagnosis, or treatment. And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Verywell Health's content is for informational and educational purposes only. Nevertheless, pregnant women, those allergic to the Asteraceae family of plants, those with diabetes and anyone with an estrogen-sensitive condition should seek medical advice before taking it. The terms "milk thistle" and "silymarin" are often used interchangeably. 2008;47(2):605-12. doi:10.1002/hep.22044, Fried MW, Navarro VJ, Afdhal N, et al. Brain Fog (anxiety, depression, ADHD), lots of medications. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. *These statements have not been evaluated by the Food and Drug Administration. The .gov means its official. Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Benefits. Eighteen clinical trials of 1,088 participants were assessed. However, many of these potential benefits are not backed by science. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. Subjects were assessed with the National Institute of Mental Health Trichotillomania Severity Scale (primary outcome), the Massachusetts General Hospital Hair Pulling Scale, Clinical Global Impression scale, and measures of depression, anxiety, and psychosocial . Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). 2023 Natural Wellness. All rights reserved. Milk thistle is not recommended for children. #1: Milk thistle detoxifies the liver. Epub 2019 Nov 24. There are no other food sources of this herb. Silymarin is an antioxidant compound taken from milk thistle seeds. Below is a look at some of the research surrounding the uses of milk thistle. doi:10.1097/CAD.0000000000000211, Fallah M, Davoodvandi A, Nikmanzar S, et al. The irony of this list of side effects being associated with drugs intended to treat anxiety, depression, and OCD is not lost on us, and ultimately begs the question, What naturally helps OCD?. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. Store at room temperature away from moisture, heat, and light. FOIA Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Do not use more of this product than is recommended on the label. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Fried, M.; Navarro, V.; Afdhal, N. et al. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. This content does not have an English version. The best doses of milk thistle have not been established for any condition it may be used to treat. Bookmark the permalink. As a liver support and liver aid, milk thistle acts as a powerful liver cleanser by rebuilding liver cells, reducing liver damage and removing toxins from the body that are processed through the liver. Rev Diabet Stud. Unexpected effects from milk thistle. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. . While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). de Avelar CR, Pereira EM, de Farias Costa PR, et al. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). In fact, a recent review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control (44). . (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. Generic name: milk thistle [MILK-THIH-sull] Accessed Oct. 30, 2020. Milk thistle and its antioxidant properties are promising in managing OCD symptoms but it may also be beneficial to explore other herbs for OCD treatment to bolster and round out a supplement regimen. There is also concern that milk thistle might affect estrogen levels. Clipboard, Search History, and several other advanced features are temporarily unavailable. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Would you like email updates of new search results? Milk Thistle Tea: Benefits, Side Effects, and Dosage. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Exercise caution and start slow. . Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. Silibinin-treatment up-regulated the function through BDNF/TrkB pathway and attenuated autophagy in the hippocampus. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). Accessed Oct. 30, 2020. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Therefore, it may be best to avoid milk thistle during these life stages. I think milk thistle is often used in combo with NAC to enhance it's beneficial effects. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). It is not intended to substitute for the medical expertise and advice of your health care provider(s). Careers. Facts & Comparisons eAnswers. Nat Neurosci. Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Silymarin is an active component of milk thistle, which is not found in foods. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. Have direct benefits against prostate, breast, and certain cervical cancer cells. However, research is not conclusive on its uses. https://www.nccih.nih.gov/health/milk-thistle. Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. Someone please correct me if I'm wrong. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. Osteoporosis is a disease caused by progressive bone loss. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. See additional information. After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. 2005 - 2023 WebMD LLC, an Internet Brands company. Join 45,000+ subscribers and receive the latest, useful and exclusive health and wellness articles, health tips, special offers and more - delivered direct to your inbox. Learn more about natural remedies for type 2 diabetes. This flowering plant can help control blood sugar levels and enhance bone health. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Acne is a chronic inflammatory skin condition. Scan J Gastroenterol. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Written by Cerner Multum. 2023 Healthline Media LLC. government site. Keywords: "It helps to clear out the toxins and nourish the organ," says Justice. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. alton recycling centre booking, i am here opening line novel,
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